Results of the Calls for Proposals

2026

Innovation

  • Toward Stable “Naked” M3+ Tri-Cations? Modeling and Experimental Studies | Alain CHAUMONT
  • Unraveling the complex mechanisms behind the formation of synthetic and biological nanosized materials using in situ liquid-phase electron microscopy | Ovidiu ERSEN
  • Microplastics as Modifiers of Macrophage and Endothelial Function in Coronary Disease | Petra HELLWIG
  • Establishment of the Klymchenko Team for Photoactive Materials and Bioimaging at the Institute Le Bel | Andrey KLYMCHENKO

ITI SysChem – Chemistry of Complex Systems

  • The Role of Amino Acid Chirality in Protein Aging | Vladimir TORBEEV
  • Molecular devices based on a homochiral-heterochiral switch within trinuclear titanium(IV) self-assembled architectures | Pierre MOBIAN
  • Stitching pillar[5]arene derivatives to create knotted structures | Jean-François NIERENGARTEN
  • CHIROGENS – Axially chiral viologens: electrochemical and photophysical enantioselective properties | Giulio RAGAZZON
  • Light-Activated Ru-Peptide Macrocycles Combining Targeting and Cytotoxicity | Irene REGENI

ITI SysChem – Emerging Investigators

  • Supramolecular Control of Charge-Transfer-Enabled Decarboxylative Arylation (2026) | Nicolas KERN

Establishment of new research teams in Strasbourg

  • Amino Acid Regulation of Complex Intracellular Protein Networks | Xufeng XU

2025

Local Synergy

Enables the joint purchase of small items of equipment for the benefit of the community:

  • NMR LED Probe for In Situ (Supra)Molecular Characterization of Light-Responsive Systems
  • FTIR microscope for structural studies of self-assemblies and the dynamics of complex systems
  • Nanostructuring and Handling of Nanomaterials
  • Mechanochemical Functionalization of Carbon Electrode Materials via High-Energy Ball Milling

Innovation

Funds the most innovative projects in chemistry

  • Harnessing the Reactivity of “Super-sugars” in Novel Complexity-Generating Cascade Reactions | Philippe COMAPIN
  • SAFERSUN: Toward a New Methodology for Assessing the Photoallergic and Phototoxic Risks of Chemicals in Consumer Products | Elena GIMENEZ-ARNAU
  • Crafting Chiral Complexity: A Synthetic Toolbox for Advanced Aza-Silaheterocycles | Frédéric LEROUX
  • Toward New Antibiotics Against Anthrax and Plague | Myriam SEEMANN

ITI SysChem – Chemistry of Complex Systems

Supports the most ambitious projects in this field

  • Playing with—and learning from—motorized molecular toys (PLAYMOBIL) | Nicolas GIUSEPPONE
  • Developing a coupled nanodisc and electrochemical approach for the study of membrane proteins from the respiratory chain that catalyze oxygen reduction | Petra HELLWIG
  • Sigma-Bond Cleavage Strategies for Alkaloid Skeletal Editing | Amir HOVEYDA
  • Conformational Complexity of the Disordered N-Terminal Region in the Biological Function of the Tumor Suppressor Protein p53 (“p53 Complexity”) | Vladimir TORBEEV

ITI SysChem – Emerging Investigators

Supports talented young researchers who wish to develop their independence in the field of complex systems chemistry

  • Chiral metallosupramolecular architectures based on copper iodide nanoclusters as new earth-abundant metal-based CPL emitters | Aurélie GUENET

Establishment of new research teams in Strasbourg

  • Organometallic Catalysis, Organic Synthesis, and Health | Stefan CHASSAING
  • Chemistry of Photoresponsive Systems | Mayeul COLLOT
  • Functional Metal-Peptide Assemblies | Irene REGENI
  • Novel Self-Labeling Proteins for Chemical Biology Applications | Adrian SALIC

2024

Local Synergy

Enables the joint purchase of small items of equipment for the benefit of the community:

  • Flow Cytometer | Dominique BONNET
  • Spectrofluorimeter | Frédéric LEROUX
  • Microfluidic platform | Alain WAGNER

Innovation

Funds the most innovative projects in chemistry

  • Exploring the Relationship Between Properties and Structure Using a Combinatorial Library of Elastin-Like Peptides | Fouzia BOULMEDAIS
  • Compact Biomacromolecule-Based Materials for Tissue Engineering | Benoit FRISCH
  • Visible-Light-Induced Activation of CF3-N-allenamides to Promote [2+2] Cycloadditions | Laurence Miesch
  • Exploiting the IspG Metalloenzyme Using Innovative Molecular Tools as a Source of Inspiration for Unprecedented Antibacterial Agents | Myriam SEEMANN

Chemistry of Complex Systems

Supports the most ambitious projects in this field

  • Homoleptic N-heterocyclic carbene complexes of Group 4 and 14 as effective alternative photosensitizers to heavy metals | Stéphane BELLEMIN-LAPONNAZ
  • CHIRALSPIN | Athanassios BOUDALIS
  • Supramolecular Chirogenesis: Switchable CD and CPL in Multi-Responsive Receptors | Valérie HEITZ
  • Polymeric Nanoparticles with Dynamic Covalent Chemistry for Molecular Recognition and Fluorescence Detection of Neurotransmitters | Andrey KLYMCHENKO
  • Photoelectrocatalytic Reduction of NOx Catalyzed by Polyoxometalates: Mechanism Insights, In Situ Characterization by Differential Electrochemical Mass Spectrometry | Laurent RUHLMANN
  • Enzyme-triggered membrane-less organelle formation with high protein partitioning | Pierre SCHAAF
  • Exploiting bacterial iron uptake pathways to deliver drugs: Investigating the expression of bacterial iron uptake pathways at the single-cell level | Isabelle SCHALK

Emerging Investigators

Supports talented young researchers who wish to develop their independence in the field of complex systems chemistry

  • Exploring Spin Communication in Photogenerated Triplet-Radical Systems Based on Naphthalene Diimides | Rodrigo VARGAS JENTZSCH

2023

Local Synergy

Enables the joint purchase of small items of equipment for the benefit of the community:

  • Differential Refractive Index Detector for Size Exclusion Chromatography | Fouzia BOULMEDAIS
  • Electron microscopy platform for the in-situ study of nanomaterials | Ovidiu ERSEN

Innovation

Funds the most innovative projects in chemistry

  • Mechanosynthesis and Wafer Shaping of 2D and Mixed 2D/3D Hybrid Perovskites for the Design of a New X-Ray Detector with Improved Stability and Performance | Sylvie BEGIN-COLIN
  • Atropisomeric halogen bond donors | Xavier BUGAUT
  • Quantified Noncovalent Interactions for Predicting Reactivity | Jean-Pierre DJUKIC
  • Eight-shaped pillar[10]arene analogs: synthesis and incorporation into Solomon links | Jean-François NIERENGARTEN

Chemistry of Complex Systems

Supports the most ambitious projects in this field

  • Broad-spectrum antiviral coatings using chemically modified graphene | Alberto BIANCO
  • Toward a Molecular Understanding of Synaptic Transduction | Marco CECCHINI
  • Symmetry and Chirality under Strong Coupling | Thomas EBBESEN
  • Driving (Supra)Molecular Systems Uphill with Artificial Molecular Motors (DreamUp) | Nicolas GIUSEPPONE
  • Detection of Catalytic Reactions in Membrane Proteins in Biomimetic Plasmonic Nanopores Using Infrared Microscopy | Petra HELLWIG
  • ATP-Fuelled Artificial Non-Equilibrium Systems (FASt) | Giulio RAGAZZON
  • Versatile Molecular Spin States for Spin Qubits | Vincent ROBERT
  • Stable air-radical ion pairs for supramolecular nanomaterials | Jean WEISS

Emerging Investigators

Supports talented young researchers who wish to develop their independence in the field of complex systems chemistry

  • Acridinium pi-dimer for Large-Amplitude Motion on Surfaces | Henri-Pierre JACQUOT

2022

Local Synergy

Enables the joint purchase of small items of equipment for the benefit of the community:

  • NIR-sensitive spectrofluorometer for accurate photophysical characterization of NIR-emitting dyes and particles | Luc LEBEAU
  • Upgrade of the magnet for the research spectrometer at the Cronenbourg NMR Core Facility | Frédéric LEROUX

Innovation

Funds the most innovative projects in chemistry

  • Anisotropic Properties of Complex Self-Assembled Nanocellulose-Based Materials | Olivier FELIX
  • SN2′-Reactions on Polyfluorinated N-Allenamides to Generate 1,1-Difluoroalkene Carbonyl Mimics | Laurence MIESCH
  • The Hidden Treasure of λ3-Chloranes: A New Horizon for Synthetic Chemistry | Joanna WENCEL-DELORD

Chemistry of Complex Systems

Supports the most ambitious projects in this field

  • Structural Analysis of Peptide-Lipid Nanoparticles with a Range of Therapeutic Activities | Burkard BECHINGER
  • Prebiotic ecosystems of synergistic early cells | Claudia BONFIO
  • Enantioselective Beta-Arylation of Alcohols via the Productive Combination of Relay Ru/Rh Catalysis and Dynamic Kinetic Resolution of Transient Alpha-Aryl Aldehydes | Pawel DYDIO
  • Understanding the Importance of Thiols for Biologically Active Copper-Ligand Complexes | Peter FALLER
  • Strong-CPL: Enhancing Circularly Polarized Luminescence via Strong Coupling | Cyriaque GENET
  • Innovative Development of Light-Gated Piezo Channels with Chemical Photoswitches | Thomas GRUTTER
  • Molecularly Engineered Biradicals as Two-Qubit Gates (QBIRAD) | Mario RUBEN
  • Harnessing Chemical Complexity in High-Performance Flexible Rechargeable Zn-Ion Batteries (ComplexZnBatt) | Paolo SAMORI
  • Micropatterning Controlled by Enzyme-Assisted Self-Assembly Through Liesegang-Like Processes | Pierre SCHAAF
  • Protein Complex with Rotaxane-Like Polypeptide Chain Topology: Design, Synthesis, Biophysical Properties, and In Vivo Applications | Vladimir TORBEEV

Emerging Investigators

Supports talented young researchers who wish to develop their independence in the field of complex systems chemistry

  • Self-Assembling De Novo Peptides as Innovative Crystallization Scaffolds | Vincent LEBRUN

Establishment of new research teams in Strasbourg

  • Enantioselective Oxidative Aromatization | Xavier BUGAUT

2021

Local Synergy

Enables the joint purchase of small items of equipment for the benefit of the community: no projects were selected

Innovation

Funds the most innovative projects in chemistry

  • Lignin-based Covalent Adaptive Networks (LigniCAN) | Luc AVEROUS
  • Design of Self-Assembled Thermoresponsive Macromolecular Nanostructures for the Delivery of Essential Oils (THEOS) | Fouzia BOULMEDAIS
  • Development of a Fully Catalytic Method for Enantioselective Difluoromethylation to Produce Difluoromethylated Bioisosteres (DiFluChir) | Frédéric LEROUX
  • Site-specific monitoring of RNA G-quadruplex dynamics and interactions with an isomorphic fluorescent nucleoside analog | Yves MELY
  • Transition Metal/Oxide Heterostructures for the Electrocatalysis of Complex Fuel Oxidation | Elena SAVINOVA

Chemistry of Complex Systems

Supports the most ambitious projects in this field

  • Case Studies of Nonlinear Effects in Asymmetric Catalysis: Elucidating Principles and Applications | Stéphane BELLEMIN-LAPONNAZ
  • Photothermal Therapy Mediated by Multifunctional 2D Materials | Alberto BIANCO
  • Complex out-of-equilibrium molecular rotors | Nicolas GIUSEPPONE
  • ATP-Controlled Erasing and Rewriting in Macromolecular Information Networks | Jean-François LUTZ
  • Controlling Regioselectivity through Strong Vibrational Coupling | Joseph MORAN
  • SUPRA: Supermolecularly Engineered Chemical Sensors Based on Metal Nanoparticles for the Detection of Metal Ions (SUPRASENS) | Paolo SAMORI

Emerging Investigators

Supports talented young researchers who wish to develop their independence in the field of complex systems chemistry

  • Pi-Anion Interactions as a Design Principle for Organometallic Catalysts | David LEBOEUF
  • 89Zr-labeled radioimmunoconjugates with bispidine ligands | Aline NONAT

Establishment of new research teams in Strasbourg

  • Toward the Emergence of Modern Cells | Claudia BONFIO
  • Assembly of Kinetically-Trapped Nanomaterials (AKIN) | Giulio RAGAZZON

2020

Local Synergy

Enables the joint purchase of small items of equipment for the benefit of the community

  • Ultraclean van der Waals Heterostructures | Bernard DOUDIN
  • Liquid Chromatography Coupled with Mass Spectrometry for Sensitive and Accurate Peptide Analysis | Peter FALLER
  • State-of-the-Art Computational Tools for a Better Understanding of Experimental Results | Marc HENRY
  • Improvements to the Cronenbourg NMR Facility | Frédéric LEROUX

Innovation

Funds the most innovative projects in chemistry

  • A Unified Approach to Nogalamycin-Related Anthracyclines through Reactions Initiated by Catalytic Hydrogen Atom Transfer | Philippe COMPAIN
  • Ultrafast Spectroscopy of Conical Intersections in Biomimetic Photoswitches | Stefan HAACKE
  • In Situ Chemical Reactivity of p-Phenylenediamine, a Major Skin Sensitizer, in Reconstructed Human Epidermis: A Quantitative HRMAS NMR Approach | Jean-Pierre LEPOITTEVIN
  • Atomic-scale magnetometry using a single-molecule spin sensor | Laurent LIMOT

Chemistry of Complex Systems

Supports the most ambitious projects in this field

  • Enantio- and Chemoselective Supramolecular Catalysis in Water Using Metal Nanoparticles Stabilized with SPO-Capped Cyclodextrins | Dominique ARMSPACH
  • Allosterically Controlled Synthesis and Properties of [2]Rotaxanes | Valérie HEITZ
  • Giant molecular machines | Jean-François NIERENGARTEN
  • Deciphering Protein-Protein Interactions Involving Intrinsically Disordered Proteins | Vladimir TORBEEV
  • Organo- and Metallocatalysis for C-Glycosides | Patrick PALE
  • New Strategy for Gene Therapy in the Lung | Luc LEBEAU
  • Structural Foundations of Peptide-Based Membrane Mesophases with Significantly Enhanced Biological Activities | Burkhard BECHINGER
  • Combating Antibiotic Resistance by Targeting the Bacterial LytB Enzyme | Myriam SEEMANN

Emerging Investigators

Supports talented young researchers who wish to develop their independence in the field of complex systems chemistry

  • Heterogeneous Reusable Catalysts Containing Gold Nanoparticles for C-Heteroatom Bond-Forming Reactions | Gaelle BLOND
  • Flow Chemistry for Prebiotic Complex Systems | Kamila MUCHOWSKA
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